WP8 - Use case: Personalized Medicine - integrating complex data sets to understand disease pathogenesis and improve biomarker and treatment selection

Task 1. Develop a process for secure sharing of and access to PM data

Building on the work carried out in WP5 Secure access, a process will be developed by which a producer of the data can share and the user of the data can gain access to the PM data in a secure and legal, yet easiest possible manner. FIMM will have the role of a prototype PM data provider as well as a user. TUM, as the leader of WP5 will provide expertise in privacy protection as well as secure sharing and access matters.

Task 2. Define types of PM data and mapping between them

Measurements made with different technologies may not be (and usually are not) directly comparable, even though the underlying thing measured (e.g. certain mRNA level) may be exactly the same. This creates a situation where a user of the data may inadvertently be “comparing apples with oranges”. To avoid that, data types (as well as pertinent standards) relevant to PM will be catalogued and mapping between them provided, if applicable. FIMM will provide PM domain expertise. KI, as the leader of the Standards work package (WP3), will provide know-how of existing standards.

Task 3. Develop a PM informatics pipeline

As a proof of concept that the tasks above facilitate the interoperability of different PM data types, a prototype PM informatics pipeline to support the decision making process in PM will be developed. This prototype pipeline will utilise the data type specifications and standards established in Task 2 and be subject to constraints of access procedures established in Task 1. FIMM will be a prototype PM data producer and user. EMBL-EBI as the leader of Technical Integration work package (WP4) will provide expertise on general framework and architecture of the implementation.