translational research

Visualise health consequences of mutations in protein structures

ssuhr@ebi.ac.uk — Wed, 18 Mar 2015 10:38:53 +0000

PLan-Variants

This pilot web service bridges the disciplines of clinical genetics and structural biology by displaying the health consequences of mutations as annotations on a protein structure.

Unlocking data from mouse disease models: diabetes ontology

ssuhr@ebi.ac.uk — Wed, 11 Mar 2015 14:08:29 +0000

The BioMedBridges diabetes-specific ontology enables users to integrate mouse disease model and human data resources while taking into account the different temporal stages of human disease.

Unlocking small-molecule resources

ssuhr@ebi.ac.uk — Wed, 04 Feb 2015 16:49:40 +0000

The UniChem connectivity search function allows users to find not only exact matches of their chemical structure across 60 million related molecules from 21 data sources worldwide, but also identifies 'equivalent' structures that have the same atom connectivity while differing in stereochemistry or isotopic composition, or which exist in a different salt form. This functionality is particularly important in the development of new pharmaceuticals, where early candidate triage can save significant amounts of time and money.