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Visualise health consequences of mutations in protein structures | BioMedBridges

Visualise health consequences of mutations in protein structures

PLan-Variants

This pilot web service bridges the disciplines of clinical genetics and structural biology by displaying the health consequences of mutations as annotations on a protein structure.

PLan-Variants integrates data from the Protein Data Bank and ClinVar, which aggregates information about genomic variation and its relationship to human health. You can see this for the Crystal Structure of a PALB2/BRCA2 complex here: PDB id 3eu7.

Further information